Rochester, Minn.: Mayo Foundation for Medical Education and Research 2016. Philadelphia, Pa.: Saunders Elsevier 2016. In: Murray and Nadel's Textbook of Respiratory Medicine. What is COPD? National Heart, Lung, and Blood Institute.In addition to reducing the amount of space available for the lung to expand, giant bullae can increase your risk of pneumothorax. Some people with emphysema develop empty spaces in the lungs called bullae. This can cause a condition called cor pulmonale, in which a section of the heart expands and weakens. Emphysema can increase the pressure in the arteries that connect the heart and lungs. This is uncommon but serious when it occurs. A collapsed lung can be life-threatening in people who have severe emphysema, because the function of their lungs is already so compromised. People who have emphysema are also more likely to develop: Breathing indoor pollutants, such as fumes from heating fuel, as well as outdoor pollutants - car exhaust, for instance - increases your risk of emphysema. Exposure to indoor and outdoor pollution.If you breathe fumes from certain chemicals or dust from grain, cotton, wood or mining products, you're more likely to develop emphysema.
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